If a dad or mum in the proband is understood to have the pathogenic variant discovered from the proband, the danger towards the sibs of inheriting the pathogenic variant is 50%. As a result of lessened penetrance, sibs who inherit the pathogenic variant may or may not acquire aHUS (see https://air-handling-unit-ahu-hir65319.blogstival.com/54096909/examine-this-report-on-air-handling-units-ahus