Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts through the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have recognized recurrent mutations in genes regulating tumor cell-microenvironment intera... https://nathaniela086yhp4.blog-eye.com/profile