Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators with the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interactions,... https://warrenm665gxq7.blogsmine.com/profile