Evidence-based professional reference pages authored by our clinical team for the use of medical professionals. An acute exacerbation is more commonly known kakım a 'flare-up'. An acute exacerbation of chronic obstructive pulmonary disease (COPD) is a sudden worsening of COPD symptoms compared with the usual severity of symptoms. Before using https://www.webwiki.it/tr.wikipedia.org/wiki/Vitamin