The neurologic phenotype in SCA8 BAC enlargement although not BAC Command strains demonstrated the pathogenicity with the (CTG-CAG)n enlargement. Additionally, the expression of noncoding (CUG)n enlargement ATXN8OS transcripts and the invention of intranuclear polyglutamine inclusions advised that SCA8 pathogenesis will involve toxic gain-of-perform mechanisms at both of those the pro... https://ewarti554ufq5.celticwiki.com/user