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Opioid activity is due to equally very low affinity binding of your mum or dad compound and better affinity binding from the O-demethylated metabolite M1 to μ-opioid receptors. In animal versions, M1 is nearly six times more potent than tramadol in generating analgesia and two hundred moments additional potent in https://legaltramadols.com/product/buy-tramadol-50-mg/

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